Check out upcoming events to hear Dr. Robert Woodbury speak on the topic of
“Emerging Concepts in Obesity”
Saturday, April 5th Northern California Medical Association Symposium
Friday, April 26th Grand Rounds @ Memorial Hospital
Here are just a few of the questions that we should be asking and Dr. Woodbury will be answering, you won’t want to miss this!
- Why does a patient suffering from gastric cancer undergo a gastrectomy and roux-enY reconstruction not lose massive amounts of weight from the surgery?
- Why des a mammal force fed into a state of morbid obesity naturally return to a normal weight after the force feeding stops?
- Why does a rodent fetus genetically designed to be immune from obesity, transplanted into a morbidly obese mother, become morbidly obese?
- How does changing the gut microflora alter the genetic expression of GABA receptors in the brain and decrease anxiety?
- Why do mammas subjected to bariatric surgery lose drastically more weight than a pair-mate mammal fed the same calorie restricted diet that the surgery animal ate?
- If gluttony is simply due to a deficiency in will-power why do bariatric patients develop profound changes that immediately correct it?
- If environment and family influences are to blame for obesity, then why do children born to mothers after bariatric surgery have less obesity, diabetes and cardiovascular risk than their sibling born before mom had bariatric surgery?
- If restricting calories were a dominant mechanism for weight loss why did the old jaw wiring surgeries and non-metabolic gastrectomies fail to cause real sustained weight loss?
If you are interested in the science behind his talk, see below for the bibliography.
Bibliography for Article and Presentation
“Emerging Concepts in Obesity” by Robert Woodbury, MD April, 2014
Centers for Disease Control. Obesity trends 2010
Ryan, Woods, and Seeley “Central nervous system mechanisms linking consumption of palatable high-fat diets to the defense of greater adiposity” Cell Metab. 2012 Feb 8;15(2) 137-149.
Seeley et al “Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding.” Am J. PHysiology, Sept 1996 vol 271. 819-823.
Williams Trust Case Control Consortium. “Genomic-wade association study of 14,000 cases of seven common diseases and 3000 shared controls”. Nature 2007; 447: 661-678
Frayling et al. “A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity”. Science 2007. 316. 889-894
Cecil JE. “An obesity associated FTO gene variant and increased energy intake in children” NEJM 2008: 359: 2558-2566
Diva, C. “Variation in the FTO contributes to childhood obesity and severe adult obesity”. Nat. Genet. 2007: 39; 724-726
Andreasen, CH. “Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation”. Diabetes 2008; 57: 95-101
Hunt, SC. “Association of the FTO gene with BMI”. Obesity Apr 2008 16(4) 902
Karra et al. “A link between FTO, ghrelin, and impaired brain food-cue responsivity.” J. Clin. Inv. Aug 2013 123(8) 3539-3551
Tamashiro et al. “Cloned mice have an obese phenotype not transmitted to their offspring.” Nat Medicine Mar 2002 8(3)
Smith, Marceau, et al. “Effects of maternal surgical weight loss in mothers on the intergenerational transmission of obesity”. J. Clin Endocrinol Metab. 2009 94(11) 4275
Kral, Marceau et al. “Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years”. Pediatric 2006 Dec 118 (6) e1644
Woodard, Morton, et al. “Probiotics improve outcomes after Roux-en-Y Gastric Bypass surgery: A prospective randomized trial. “ J. Gastrointest Surgery 2009 13:1198-1204
Lio, Kaplan et al. “Conserved shifts in gut microbiome due to gastric bypass reduce host weight and adiposity”. Sci Transl Med 2013 5:178
Molinaro et al. “Probiotics, prebiotics, energy balance, and obesity”. Gastroenterol Clin N Am 2012 (41)843-854
Jumperts “Energy balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. “ Am J Clin Nutr Jul 2011 94(1):58-65
Jayasena et al “Role of gut hormones in obesity”. Endocrinology and Metabolism Clinics of N AM 2008 37: 769-787
Mikalakis and le Roux “Gut hormones and leptin: Impact on energy control and changes after bariatric surgery – what the future holds. “ Obes Surg 2012 22: 1648-1657
Gallwitz and Schmidt “GLP-1 receptor knock-out causes glucose intolerance but no alterations of eating behavior”. Z Gastroenterolgy 1997; 35: 655
Cohen et al. “Effect of gastric bypass surgery in patients with type 2 diabetes and only mild obesity”. Diabetes Care 2012; 35(7) 1420-1428
Sumithran et al. “Long term persistence of hormonal adaptations to weight loss”. NEJM 2011 365(17) 1597-1604
ORourke,Robert OHSU. Presentation at ASMBS 2012. Based on his article. O’Rourke “Inflammation in obesity-related disease. Surgery 2009 March; 145(3) 255-259
Speaker and Fleshner. “Interleukin-1 Beta: a potential link between stress and the development of visceral obesity. BMC Physiology 2012 12:8
Ahima et al. “Brain regulation of appetite and satiety”. Endocrin Metab Clinics N. Am. 2008 (37)811
Mikalakis and leRoux. “Gut hormones and leptin: Impact on energy control and changes after bariatric surgery, what the future holds.” Obes Surg 2012 22:1648-1657
Seeley and Kaplan. Presentation at Metabolic Applied Research Strategy Conference June 2010
Kaplan. “Effect of surgical and non-surgical weight loss on energy expenditure”. Presentation at Metabolic Applied Research Strategy, June 2012. Based on much of his own unpublished and published work including: Mirshahi et al “The MC4R Allele is associated with better metabolic status and more weight loss after gastric bypass surgery. J Clin Endocrin Metab Dec 2011; 96(12) E2088-E2096
Hatoum et al. “Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery” J. Clin Endocrinolgy Metab 2012
Periera, et al. “Effects of a low glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss. JAMA. Nov 24, 2004. vol 292 #20
Stylopoulous et al “Roux-en-Y gastric bypass enhances energy expenditure and extend lifespan in diet-induced obese rats”. Obesity 2009; 17(10): 1839-1847
Shin et al. “Longitudinal assessment of food intake, fecal energy loss, and energy expenditure after roux-en-y gastric bypass surgery in high fat fed obese rats.” Obesity surg Apr 2013; 23(4) 531-540