Scientific References

Weight loss with a low-carbohydrate, mediterranean, or low-fat diet. New England Journal of Medicine, 2008

Effects of low glycemic diet on resting energy expenditure and heart disease risk factors during weight loss. Journal of American Medical Association, 2004

Adiposity as compared with physical activity in predicting mortality among women. New England Journal of Medicine, 2004

A clinical trial of the effects of dietary patterns on high blood pressure. New England Journal of Medicine, 1997

Effects of comprehensive lifestyle modification on blood pressure control. Journal of American Medical Association, 2003

Effect of comprehensive therapeutic lifestyle changes on prehypertension. American Journal of Cardiology, 2008

Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. British Journal of Nutrition, 2010

Probiotics improve outcomes after roux-en-Y gastric bypass: A prospective randomized trial. Journal of Gastrointestinal Surgery 2009

Reduction in the incidence of type-2 diabetes with lifestyle intervention or metformin. New England Journal of Medicine, 2002

Changes in diet and lifestyle and long-term weight gain in women and men. New England Journal of Medicine, 2011

Prevention of type-2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England Journal of Medicine, 2001

Adherence to a mediterranean diet and survival in a greek population. New England Journal of Medicine, 2003

Effects of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome. Journal of the American Medical Association, 2004

Mediterranean diet, lifestyle factors, and 10-year mortality in elderly european men and women. Journal of the American Medical Association, 2004

US Food and Drug administration, section 5(b) of the Orphan Drug Act: Medical food is “a food which is formulated to be consumed under the supervision of a physician and which is intended for specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.”

Double-blind, placebo controlled trial examining the effects of RIAA/Acacia supplementation on insulin homeostasis. Functional Medicine Research Center, 2006

Enhancement of a modified mediterranean-style, low glycemic load diet with specific phytochemicals improves cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia in a randomized trial. Nutrition and Metabolism, 2008

Subjects with elevated LDL cholesterol and metabolic syndrome benefit from supplementation with soy protein, phytosterols, hops rho iso-alpha-acids, and Acacia nilotica proanthocyanidins. Journal of Clinical Lipidology, 2010

A mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism.  Journal of Clinical Lipidology, 2011